AustralieFrV1, Main, Exploration, bibRecord, 008223

Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits

Identifieur interne : 008223 ( Main/Exploration ); précédent : 008222; suivant : 008224

Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits

Auteurs : M. D. Glantz [États-Unis] ; J. C. Anthony [États-Unis] ; P. A. Berglund [États-Unis] ; L. Degenhardt [Australie] ; L. Dierker [États-Unis] ; A. Kalaydjian [États-Unis] ; K. R. Merikangas [États-Unis] ; A. M. Ruscio [États-Unis] ; J. Swendsen [France] ; R. C. Kessler [États-Unis]

Source :

Psychological medicine : (Print) [ 0033-2917 ] ; 2009.

RBID : Pascal:09-0389805

Descripteurs français

Pascal (Inist)
- Trouble psychiatrique, Facteur risque, Addiction, Prévention, Santé publique, Traitement, Substance toxicomanogène, Toxicomanie, Boisson alcoolisée, Alcoolisme, Rétrospective, Modèle simulation, Santé mentale, Environnement social, Etats-Unis, Adulte jeune, Adulte.
Wicri :
- topic : Santé publique, Toxicomanie, Boisson alcoolisée, Alcoolisme, Santé mentale, Adulte.

English descriptors

KwdEn :
- Addiction, Adult, Alcoholic beverage, Alcoholism, Drug addiction, Drug of abuse, Mental disorder, Mental health, Prevention, Public health, Retrospective, Risk factor, Simulation model, Social environment, Treatment, United States, Young adult.

Abstract

Background. Although mental disorders have been shown to predict subsequent substance disorders, it is not known whether substance disorders could be cost-effectively prevented by large-scale interventions aimed at prior mental disorders. Although experimental intervention is the only way to resolve this uncertainty, a logically prior question is whether the associations of mental disorders with subsequent substance disorders are strong enough to justify mounting such an intervention. We investigated this question in this study using simulations to estimate the number of substance disorders that might be prevented under several hypothetical intervention scenarios focused on mental disorders. Method. Data came from the National Comorbidity Survey Replication (NCS-R), a nationally representative US household survey that retrospectively assessed lifetime history and age of onset of DSM-IV mental and substance disorders. Survival analysis using retrospective age-of-onset reports was used to estimate associations of mental disorders with subsequent substance dependence. Simulations based on the models estimated effect sizes in several hypothetical intervention scenarios. Results. Although successful intervention aimed at mental disorders might prevent some proportion of substance dependence, the number of cases of mental disorder that would have to be treated to prevent a single case of substance dependence is estimated to be so high that this would not be a cost-effective way to prevent substance dependence (in the range 76-177 for anxiety-mood disorders and 40-47 for externalizing disorders). Conclusions. Treatment of prior mental disorders would not be a cost-effective way to prevent substance dependence. However, prevention of substance dependence might be considered an important secondary outcome of interventions for early-onset mental disorders.

Affiliations:

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Le document en format XML

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<term>Addiction</term>
<term>Prévention</term>
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<term>Traitement</term>
<term>Substance toxicomanogène</term>
<term>Toxicomanie</term>
<term>Boisson alcoolisée</term>
<term>Alcoolisme</term>
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<front><div type="abstract" xml:lang="en">Background. Although mental disorders have been shown to predict subsequent substance disorders, it is not known whether substance disorders could be cost-effectively prevented by large-scale interventions aimed at prior mental disorders. Although experimental intervention is the only way to resolve this uncertainty, a logically prior question is whether the associations of mental disorders with subsequent substance disorders are strong enough to justify mounting such an intervention. We investigated this question in this study using simulations to estimate the number of substance disorders that might be prevented under several hypothetical intervention scenarios focused on mental disorders. Method. Data came from the National Comorbidity Survey Replication (NCS-R), a nationally representative US household survey that retrospectively assessed lifetime history and age of onset of DSM-IV mental and substance disorders. Survival analysis using retrospective age-of-onset reports was used to estimate associations of mental disorders with subsequent substance dependence. Simulations based on the models estimated effect sizes in several hypothetical intervention scenarios. Results. Although successful intervention aimed at mental disorders might prevent some proportion of substance dependence, the number of cases of mental disorder that would have to be treated to prevent a single case of substance dependence is estimated to be so high that this would not be a cost-effective way to prevent substance dependence (in the range 76-177 for anxiety-mood disorders and 40-47 for externalizing disorders). Conclusions. Treatment of prior mental disorders would not be a cost-effective way to prevent substance dependence. However, prevention of substance dependence might be considered an important secondary outcome of interventions for early-onset mental disorders.</div>
</front>
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Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits

Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri